(7-Methoxy-5-Methylbenzo[b]thiophen-2-yl)boronic acid

(7-Methoxy-5-Methylbenzo[b]thiophen-2-yl)boronic acid - Names and Identifiers

Name	(7-Methoxy-5-Methylbenzo[b]thiophen-2-yl)boronic acid
Synonyms	7-Methoxy-5-methylbenzothiophene-2-boronic Acid (7-Methoxy-5-Methylbenzo[b]thiophen-2-yl)boronic acid (7-methoxy-5-methyl-1-benzothiophen-2-yl)boronic acid Boronic acid, B-(7-methoxy-5-methylbenzo[b]thien-2-yl)- (7-METHOXY-5-METHYLBENZO[B]THIOPHEN-2-YL)BORONIC ACID(WXC09074)
CAS	1443531-60-9

(7-Methoxy-5-Methylbenzo[b]thiophen-2-yl)boronic acid - Physico-chemical Properties

Molecular Formula	C10H11BO3S
Molar Mass	222.06854
Density	1.31±0.1 g/cm3(Predicted)
Boling Point	437.2±55.0 °C(Predicted)
pKa	6.92±0.30(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C

(7-Methoxy-5-Methylbenzo[b]thiophen-2-yl)boronic acid - Upstream Downstream Industry

Raw Materials	Benzenethiol, 2-methoxy-4-methyl- Isopropylboronic acid 7-Methoxy-5-Methylbenzo[b]thiophene 7-hydroxybenzothiophene-5-carboxylic acid 2-methoxy-p-toluidine (2,2-diethoxyethyl)(2-methoxy-4-methylphenyl)sulfane 2-METHOXY-4-METHYLBENZENESULFONYL CHLORIDE 5-METHYL-2-NITROANISOLE 5-Methyl-2-nitrophenol Triisopropyl borate Water
Downstream Products	BAY-1163877

(7-Methoxy-5-Methylbenzo[b]thiophen-2-yl)boronic acid - Introduction

(7-Methoxy-5-Methylbenzo [B] thiophen-2-yl)boronic acid is an organic boron compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: White crystalline solid
-Molecular formula: C10H11BO3S
-Molecular weight: 214.07g/mol
-Melting Point: about 160-165 ℃
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and dichloromethane

Use:
- (7-Methoxy-5-Methylbenzo [B] thiophen-2-yl)boronic acid is one of the commonly used boronic acid reagents in organic synthesis.
-It can be used to construct C- C bonds, for example as a substrate or reagent for Suzuki-Miyaura cross-coupling reactions.
-It can also be used to prepare biologically active molecules, such as drug candidates and pesticides.

Method:
- (7-Methoxy-5-Methylbenzo [B] thiophen-2-yl)boronic acid can be prepared by the reaction of benzothiazone and trimethylborane. Specific steps include:
1. Reaction of benzothiazone with trimethylborane under an inert atmosphere, using a base catalyst and an organic solvent, such as dimethyl sulfoxide.
2. The solid product obtained by filtration was purified by crystallization.

Safety Information:
- (7-Methoxy-5-Methylbenzo [B] thiophen-2-yl) The specific safety information of boronic acid may vary by manufacturer and supplier, so please refer to the relevant chemical Safety Data Sheet (MSDS) for detailed safety information on use and operation.
-As with any chemical, attention should be paid to its toxicity and irritation.
-When using, please wear appropriate personal protective equipment, such as laboratory gloves and glasses, and ensure that you operate in a well-ventilated place.

Last Update：2024-04-09 20:48:19